This temple that was dedicated as the Five Wounds of Our Seraphic Father St. Francis of Assisi, is closely linked to the history of the City of Angels and the Franciscans who were the founders. From this 16th century convent, the original Hall of the Pilgrims and the Chapel of the Third Order have been preserved, which are now converted into a school and library respectively. Its lateral entrance, called "La Porciuncula" is the oldest in the city. The main facade, built in the 18th century, combines stone sculptures and reliefs, with the petatillo and Talavera panels, to form one of the most representative baroque displays in Puebla. The central nave of the Templo Conventual de las Cinco Llagas de San Francisco is closed in with ribbed vaults. On the south side wall there is a huge painting with the genealogical tree of the Franciscans. The chapel attached to the sanctuary is home to a small statue of the Conquering Virgin that was brought by Hernando Cortes, and the incorrupt body of Blessed Sebastian de Aparicio.

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